The San Diego City Council on Monday approved restrictive new medical marijuana regulations that will force more than 165 dispensaries in the city to close in the near future and apply for permits to operate.

San Diego becomes the 43rd city in California to pass sweeping limitations on medical marijuana collectives, which have multiplied at a speed that has alarmed city officials, reports Christopher Cadelago at Sign On San Diego. At least 214 California cities have permanent bans on the facilities, according to the Coalition for a Drug Free California.